A specific mutation in the new coronavirus can significantly increase its ability to infect cells, according to a study by US researchers.
The research may explain why early outbreaks in some parts of the world did not end up overwhelming health systems as much as other outbreaks in New York and Italy, according to experts at Scripps Research.
The mutation, named D614G, increased the number of “spikes” on the coronavirus that gives the virus its distinctive shape. Those spikes are what allow the virus to bind to and infect cells.
“The number – or density – of functional spikes on the virus is four or five times greater due to this mutation,” said Hyeryun Choe, one of the senior authors of the study.
The researchers say that it is still unknown whether this small mutation affects the severity of symptoms of infected people, or increases mortality.
The researchers conducting lab experiments say that more research, including controlled studies – widely considered a gold standard for clinical trials – needs to be done to confirm their findings from test tube experiments.
Older research has showed that the new coronavirus Sars-CoV-2 is mutating and evolving as it adapts to its human hosts. The D614G mutation in particular has been flagged as an urgent concern because it appeared to be emerging as a dominant mutation.
The Scripps Research study is currently undergoing peer review and was released last Friday amid reports of its findings.
Meanwhile, studies of Covid-19 patients are trying to discover the potential long-term effects of having the disease caused by the coronavirus.
It’s hard to say exactly, because the coronavirus is still so new that scientists don’t know much about long-term effects. The best evidence comes from patients themselves, and some experience a variety of symptoms long after their infections have cleared.
Most people recover within a few weeks. For people who experience longer-term effects, the most common issues are bouts of exhaustion, headaches, anxiety and muscle aches that can last for at least several more weeks.
Patients who required intensive care, including those put on ventilators or kidney dialysis, can experience more serious issues.Lung scarring can occur in people who developed pneumonia. Heart inflammation, irregular heartbeats, and worsening kidney and liver function have been reported as well. However, it’s too soon to know if those could be permanent problems.